synthesis and study of antitumor activity of substituted imidazolecarboxamides

in view of potential biological activities of small molecule polyamides, we synthesized some novel n-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamide (7a,b), and n-(2-(1-benzyl-2-(alkylthio) -1h-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamides (8a,b) as antitumor agents. the antitumor activity of compounds 7a,b and 8a,b was studied at concentrations of 0.01, 0.1 and 1 mg/ml, using the potato disk bioassay technique. vincristine at 0.25 mg/ml employed as positive control and had -67.24% tumor inhibition. maximum % inhibition for potato tumors was found to be -75.52 for 7b at 1 mg/ml.